In Tome, a small, seemingly sleepy New Mexico hamlet, Sofia and her four fated daughters reveal a world of marvels where the comic and horrific, past and present, real and fantastic coexist and collide.

Over two crowded decades, Sofia tries to hold things together following the disappearance of her husband, Domingo, he of the Clark Gable mustache and the uncontrollable gambling habit. Adventurous Esperanza, Chicana campus radical turned television news reporter, travels farthest from home only to be reeled back in spirit. Beautiful Caridad, a nurse who dulls the pain of being jilted with nightly bouts of alcohol and anonymous sex finally finds love again―and a sharp drop off a tall cliff. Practical Fe, dutiful bank worker who wishes more than anything for stability, upon being dumped by her fiancé, lets out a year-long primal scream. And mysterious La Loca, dies (maybe?) and is resurrected at age three, leaving her both attuned to higher spiritual frequencies and allergic to human touch.